@ id death_toll event Location date_range disease lasted(years)
  0001 75,000–100,000 Plague of Athens Greece 429–426 BC 3
  0002 5–10 million Antonine Plague Roman Empire 165–180 (possibly up to 190) Unknown, possibly smallpox 15
  0003 Plague of Cyprian Europe 250–266 Unknown, possibly smallpox 16
  0004 25–50 million; 40% of population Plague of Justinian Europe ,Egypt and West Asia 541–542 Plague 1
  0005 Roman Plague of 590 Rome 590 Plague 1
  0006 > 100,000 Plague of Sheroe Ctesiphon, Persia 627–628 Plague 1
  0007 Plague of 664 British Isles 664–689 Plague 22
  0008 735–737 Japanese smallpox epidemic Japan 735–737 Smallpox 2
  0009 Plague of 746–747 Byzantine Empire , West Asia ,Africa 746–747 Plague 1
  0010 75–200 million; 30–60% of population Black Death Europe , Asia and North Africa 1331–1353 Plague 22
  0011 > 10 000 Sweating sickness (multiple outbreaks) England and later continental Europe 1485–1551 Unknown, possibly an unknown species of hantavirus 66
  0012 5–15 million (80% of population) Cocoliztli Epidemic of 1545–1548 Mexico 1545–1548 Possibly Salmonella enterica 3
  0013 > 20,100 in London 1563 London plague London 1563–1564 Plague 1
  0014 2–2.5 million (50% of population) Cocoliztli epidemic of 1576 Mexico 1576–1580 Possibly Salmonella enterica 4
  0015 Seneca nation 1592–1596 Measles 4
  0016 > 19,900 in London and outer parishes 1592–93 London plague London 1592–1593 Plague 1
  0017 Spain 1596–1602 Plague 6
  0018 South America 1600–1650 Malaria 50
  0019 England 1603 Plague 1
  0020 Egypt 1609 Plague 1
  0021 30–90% of population 1616 New England epidemic Southern New England, especially the Wampanoag people 1616–1619 3
  0022 280,000 Italian plague of 1629–1631 Italy 1629–1631 Plague 2
  0023 Wyandot people 1634 Smallpox 1
  0024 Massachusetts smallpox epidemic Thirteen Colonies 1633 Smallpox 1
  0025 England 1636 Plague 1
  0026 China 1641–1644 Plague 3
  0027 Great Plague of Seville Spain 1647–1652 Plague 5
  0028 Central America 1648 Yellow fever 1
  0029 Naples Plague Italy 1656 Plague 1
  0030 Thirteen Colonies 1657 Measles 1
  0031 24,148 Netherlands 1663–1664 Plague 1
  0032 100,000 Great Plague of London England 1665–1666 Plague 1
  0033 40,000 France 1668 Plague 1
  0034 Spain 1676–1685 Plague 9
  0035 76,000 Great Plague of Vienna Austria 1679 Plague 1
  0036 Thirteen Colonies 1687 Measles 1
  0037 Thirteen Colonies 1690 Yellow fever 1
  0038 Canada, New France 1702–1703 Smallpox 1
  0039 > 18,000 (36% of population) Great Smallpox Epidemic Iceland 1707–1709 Smallpox 2
  0040 Great Northern War plague outbreak Denmark,Sweden 1710–1712 Plague 2
  0041 Thirteen Colonies 1713–1715 Measles 2
  0042 Canada, New France 1714–1715 Measles 1
  0043 Great Plague of Marseille France 1720–1722 Plague 2
  0044 Thirteen Colonies 1721–1722 Smallpox 49
  0045 Thirteen Colonies 1729 Measles 1
  0046 Spain 1730 Yellow fever 1
  0047 Thirteen Colonies 1732–1733 Influenza 1
  0048 Canada, New France 1733 Smallpox 1
  0049 > 50,000 Great Plague of 1738 Balkans 1738 Plague 1
  0050 Thirteen Colonies 1738 Smallpox 1