@ id death_toll event Location date_range disease lasted(years)
  0112 Third plague pandemic Worldwide 1855–1960 Bubonic plague 105
  0011 > 10 000 Sweating sickness (multiple outbreaks) England and later continental Europe 1485–1551 Unknown, possibly an unknown species of hantavirus 66
  0156 > 30,000,000 HIV/AIDS pandemic worldwide 1960–present HIV/AIDS 60
  0018 South America 1600–1650 Malaria 50
  0044 Thirteen Colonies 1721–1722 Smallpox 49
  0132 > 800,000 Sixth cholera pandemic Europe, Asia, Africa 1899–1923 Cholera 24
  0007 Plague of 664 British Isles 664–689 Plague 22
  0010 75–200 million; 30–60% of population Black Death Europe , Asia and North Africa 1331–1353 Plague 22
  0085 > 100,000 Second cholera pandemic Asia, Europe, North America 1829–1851 Cholera 22
  0134 Uganda 1900–1920 Trypanosomiasis 20
  0122 Argentina 1852–1871 Yellow fever 19
  0003 Plague of Cyprian Europe 250–266 Unknown, possibly smallpox 16
  0117 Fourth cholera pandemic Middle East 1863–1879 Cholera 16
  0002 5–10 million Antonine Plague Roman Empire 165–180 (possibly up to 190) Unknown, possibly smallpox 15
  0127 > 9,000 Fifth cholera pandemic India, Germany 1881–1896 Cholera 15
  0149 Seventh cholera pandemic worldwide 1961–1975 Cholera 14
  0139 1.5 million 1915 Encephalitis lethargica pandemic worldwide 1915–1926 Encephalitis lethargica 11
  0078 > 100,000 First cholera pandemic Asia, Europe 1816–1826 Cholera 10
  0131 Congo Basin 1896–1906 Trypanosomiasis 10
  0157 South America 1990s Cholera 10
  0208 9,985 (May 2017) Haiti cholera outbreak Hispaniola 2010–present Cholera 10
  0034 Spain 1676–1685 Plague 9
  0197 China 2008-2017 Hand, foot and mouth disease 9
  0209 > 4,500 (February 2014) Democratic Republic of the Congo 2011–present Measles 9
  0210 170 Vietnam 2011–present Hand, foot and mouth disease 9
  0107 1,000,000 Third cholera pandemic Russia 1852–1860 Cholera 8
  0213 862 (as of 13 January 2020) 2012 Middle East respiratory syndrome coronavirus outbreak Worldwide 2012–present Middle East respiratory syndrome 8
  0017 Spain 1596–1602 Plague 6
  0084 Iran 1829–1835 Bubonic plague 6
  0027 Great Plague of Seville Spain 1647–1652 Plague 5
  0069 Yellow Fever Epidemic of 1793, resurgences United States 1793–1798 Yellow fever 5
  0159 231 worldwide 1996-2001 vCJD 5
  0015 Seneca nation 1592–1596 Measles 4
  0014 2–2.5 million (50% of population) Cocoliztli epidemic of 1576 Mexico 1576–1580 Possibly Salmonella enterica 4
  0133 113 Third plague pandemic San Francisco 1900–1904 Bubonic plague 4
  0141 Russia 1918–1922 Typhus 4
  0221 3,886 (as of 30 November 2019) 2016–17 Yemen cholera outbreak Yemen 2016–present Cholera 4
  0026 China 1641–1644 Plague 3
  0001 75,000–100,000 Plague of Athens Greece 429–426 BC 3
  0021 30–90% of population 1616 New England epidemic Southern New England, especially the Wampanoag people 1616–1619 3
  0012 5–15 million (80% of population) Cocoliztli Epidemic of 1545–1548 Mexico 1545–1548 Possibly Salmonella enterica 3
  0070 Spain 1800–1803 Yellow fever 3
  0077 Ireland 1816–1819 Typhus 3
  0079 United States 1820–1823 Yellow fever 3
  0087 Plains Indians 1831–1834 Smallpox 3
  0214 >> 11,300 Ebola virus epidemic in West Africa Worldwide, primarily concentrated in West Africa 2013–2016 Ebola virus disease 3
  0216 40 2014 Madagascar plague outbreak Madagascar 2014–2017 Bubonic plague 3
  0008 735–737 Japanese smallpox epidemic Japan 735–737 Smallpox 2
  0041 Thirteen Colonies 1713–1715 Measles 2
  0040 Great Northern War plague outbreak Denmark,Sweden 1710–1712 Plague 2